1.30 Support Care Cancer. 2019 Jun 17. doi: 10.1007/s00520-019-04881-3. [Epub ahead of print] PMID:31209630 DOI:10.1007/s00520-019-04881-3 Scrambler therapy for chemotherapy neuropathy: a randomized phase II pilot trial. Loprinzi C1, Le-Rademacher JG2, Majithia N2, McMurray RP2, O’Neill CR2, Bendel MA2, Beutler A2, Lachance DH2, Cheville A2, Strick DM2, Black DF2, Tilburt JC2, Smith TJ2. 1Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA. cloprinzi@mayo.edu. 2Mayo Clinic, 200 First Street, SW, Rochester, MN, 55905, USA. Abstract INTRODUCTION: Chemotherapy-induced peripheral neuropathy (CIPN) is a prominent clinical problem, with limited effective therapies. Preliminary non-randomized clinical trial data support that Scrambler Therapy is helpful in...

1.29 Medicine (Baltimore). 2019 May;98(20):e15695. doi: 10.1097/MD.0000000000015695. PMID:31096512 DOI:10.1097/MD.0000000000015695 Scrambler therapy for the treatment of diabetic peripheral neuropathy pain: A case report. Lee YS1, Park MK, Park HS, Kim WJ. 1 Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Womans University, Ewha Womans University Mokdong Hospital, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul, Republic of Korea. AbstractRATIONALE: Neuropathy secondary to diabetes mellitus often does not respond well to conventional therapy. Scrambler therapy may be an alternative treatment for otherwise intractable neuropathy. PATIENT CONCERNS: A 45-year-old female complained of bilateral plantar foot pain. She had been treated for diabetes mellitus for 5...

1.28 Int J MS Care. 2019 Mar-Apr; 21(2): 76–80. doi: 10.7224/1537-2073.2017-083 PMCID: PMC6489430 PMID: 31049038 Case Report: Scrambler Therapy for Treatment-Resistant Central Neuropathic Pain in a Patient with Transverse Myelitis   Maureen A. Mealy, RN, Scott D. Newsome, DO, Sharon L. Kozachik, PhD, RN, Michael Levy, MD, PhD, and Thomas J. Smith, MD Corresponding author. From the Department of Neurology (MAM, SDN, ML) and Department of Oncology (TJS), Johns Hopkins University School of Medicine, Baltimore, MD, USA; and Department of Acute and Chronic Care, Johns Hopkins University School of Nursing, Baltimore, MD, USA (MAM, SLK). Correspondence: Thomas J. Smith, MD, Professor...

1.27 Integr Cancer Ther. 2019 Jan-Dec;18:1534735419845143. doi: 10.1177/1534735419845143. Inside the Scrambler Therapy, a Noninvasive Treatment of Chronic Neuropathic and Cancer Pain: From the Gate Control Theory to the Active Principle of Information. Marineo G1 1 University of Rome Tor Vergata, Rome, Italy. Abstract Scrambler therapy (ST) is an electro-analgesia therapy for the noninvasive treatment of chronic neuropathic and cancer pain based on a new generation of medical device that uses 5 artificial neurons and is based on a novel theoretical model the differs from gate control theory. The active principle with Scrambler Therapy is such that synthetic “non-pain” information is...

1.26 J Pediatr Nurs. 2018 Dec 28. pii: S0882-5963(18)30587-6. doi: 10.1016/j.pedn.2018.12.009. [Epub ahead of print] Scrambler therapy: Implications for chronic pain relief in pediatrics. Mele Cheryl1, Goldschmidt Karen2. 1 University of South Carolina, Columbia, SC, United States of America. Electronic address: melec@mailbox.sc.edu. 2 Drexel University, Philadelphia, PA, United States of America. Electronic address: Kag69@drexel.edu. PMID: 30598252 DOI: 10.1016/j.pedn.2018.12.009 … ST is a noninvasive medical device with encouraging results and may be a safe alternative to chronic refractory pain in the pediatric patient population. The majority of the research of ST in adult patients demonstrates relief of symptoms in neuropathic and...

1.25 Acta Biomed. 2018 Jun 7;89(2):180-185. doi: 10.23750/abm.v89i2.5704. Scrambler therapy in the management of somatosensory signs and symptoms related to neuropathic pain: an exploratory and prospective analysis. Russo D1, Zoratto F2, Tirocchi G3, Guarda M4. 1 Hospice, Casa di Cura “San Marco”, Latina; Italy Algology Unit, Studio Polispecialiastico “Albamedica”, Albano Laziale; Italy. d.russo@clinicasanmarco.com. 2 Hospice, Casa di Cura “San Marco”, Latina; Italy. federica.zoratto@gmail.com. 3 Algology Unit, Studio Polispecialiastico “Albamedica”, Albano Laziale; Italy. d.russo@clinicasanmarco.com. 4Hospice, Casa di Cura “San Marco”, Latina; Italy. m.guarda@clinicasanmarco.com. Abstract OBJECTIVES: Neuropathic pain is a severe and disabling health problem, often difficult to treat and characterized by...

1.24 Pediatr Blood Cancer. 2018 Apr 6:e27064. doi: 10.1002/pbc.27064. [Epub ahead of print] Scrambler therapy efficacy and safety for neuropathic pain correlated with chemotherapy-induced peripheral neuropathy in adolescents: A preliminary study. Tomasello C1, Pinto RM2, Mennini C3, Conicella E4, Stoppa F1, Raucci U4. 1 Anaesthesia and Intensive Care Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy. 2 Haematology Oncology Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy. 3 Scientific Direction, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy. 4 Pediatric Emergency Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy. Abstract PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of...

1.23 Reg Anesth Pain Med. 2018 Jan 17. doi: 10.1097/AAP.0000000000000733. [Epub ahead of print] Refractory Pain Management in Amyloid-Associated Peripheral Neuropathy. Warner NS, Watson JC, Bendel MA, Moeschler SM. Abstract OBJECTIVE: Systemic amyloidosis is a disease that often involves multiple organ systems, including the peripheral nervous system. Patients may present with severe, refractory neuropathic pain; however, the optimal treatment approach for pain for these patients remains unclear. CASE REPORT: A man with severe, refractory neuropathic pain in his bilateral upper and lower extremities and the trunk secondary to amyloid neuropathy is presented. Multiple medication trials, including neuropathic and opioid agents,...

1.22 Minerva Anestesiol. 2018 Jan 17. doi: 10.23736/S0375-9393.18.12490-4. [Epub ahead of print] Phantom limb pain successfully treated with scrambler therapy. Fabbri L1, Pirotti SP2, Rosati M2, Ruffilli N2, Maltoni M2, Ricci M3. 1 Palliative Care Unit, Hospice Valerio Grassi, AUSL della Romagna, Forlimpopoli, Forlì-Cesena, Italy – marianna.ricci@irst.emr.it. 2 Palliative Care Unit, Hospice Valerio Grassi, AUSL della Romagna, Forlimpopoli, Forlì-Cesena, Italy. 3 Palliative Care Service, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Meldola, Forlì-Cesena, Italy. CONCLUSIONS: Data of the last 15 years show that ST may represent an important therapeutic option for patients suffering from...

1.21 A A Case Rep. 2017 Dec 28. doi: 10.1213/XAA.0000000000000695. [Epub ahead of print] Scrambler Therapy for the Treatment of Chronic Central Pain: A Case Report. D’Amato SJ, Mealy MA, Erdek MA, Kozachik S, Smith TJ. Abstract Central pain syndromes affect several million people worldwide. A 52-year-old woman had central pain manifest as burning pain from her left foot to the knee for 12 years after treatment for a medullary cavernoma diagnosed after a right-sided brainstem bleeding episode. All this time, her baseline pain was 5-6/10 with spikes to 9-10/10 during activity. She underwent 10 daily Scrambler (Calmare) Therapy treatments...

1.20 Medicine (Baltimore). 2017 Nov;96(45):e8629. doi: 10.1097/MD.0000000000008629. Scrambler therapy for the treatment of neuropathic pain related to leukemia in a pediatric patient: A case report. Park HS1, Kim WJ, Kim HG, Yoo SH. 1 Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Womans University, Ewha Womans University Mokdong Hospital, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul, Republic of Korea.Abstract RATIONALE: Cancer-related neuropathic pain often responds poorly to standard pain treatments. Scrambler therapy has relieved refractory chronic pain in several uncontrolled clinical trials. PATIENT CONCERNS: An 11-year-old female patient was suffering from left groin and medial thigh pain after irradiation to the...

1.19 Cureus. 2017 Jun 21;9(6):e1378. doi: 10.7759/cureus.1378. Scrambler Therapy for the Treatment of Chronic Post-Mastectomy Pain (cPMP). Smith T1, Cheville AL2, Loprinzi CL3, Longo-Schoberlein D1. 1 Palliative Medicine Program, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center. 2 Physical Medicine and Rehabilitation, Mayo Clinic and Foundation, Rochester, MN, USA. 3 Medical Oncology, Mayo Clinic and Foundation, Rochester, MN, USA. Abstract Chronic post-mastectomy pain (cPMP), including post-lumpectomy pain, is common with no established ways of treatment. We treated three consecutive patients referred with cPMP with scrambler therapy (ST), a non-invasive electrical neurocutaneous stimulation. Treatment was given across the area of pain following...

1.18 INDIAN J PALLIAT CARE. 2017 JAN-MAR;23(1):18-23. DOI: 10.4103/0973-1075.197948. Impact of Scrambler Therapy on Pain Management and Quality of Life in Cancer Patients: A Study of Twenty Cases. Kashyap K1, Joshi S2, Vig S1, Singh V3, Bhatnagar S1. 1Department of Onco-Anaesthesia and Palliative Medicine, Dr. B.R.A. Institute Rotary Cancer Hospital, All Institute of Medical Sciences, New Delhi, India. 2Department of Anesthesiology, BLK Super Speciality Hospital, New Delhi, India. 3Department of Biostatistics, All Institute of Medical Sciences, New Delhi, India. Abstract AIM OF THE STUDY: To study the effect of scrambler therapy on patients with chronic cancer pain. MATERIALS AND METHODS:...

1.17 Burns. 2016 Oct 15. pii: S0305-4179(16)30409-0. doi: 10.1016/j.burns.2016.09.028. [Epub ahead of print] Effects of pain Scrambler therapy for management of burn scar pruritus: A pilot study. Joo SY1, Cho YS1, Cho SR2, Kym D3, Seo CH4. 1Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine Hallym University, Seoul, Republic of Korea. 2Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. 3Burn Surgery, Burn Center, Hangang Sacred Heart Hospital, College of Medicine Hallym University, Seoul, Republic of Korea. 4Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine Hallym University,...

1.14 PAIN PRACTICE 2016 Sep;16(7):E103-9. doi: 10.1111/papr.12474. Epub 2016 Jul Scrambler Therapy(®) MC-5A for Complex Regional Pain Syndrome: Case Reports. Raucci U1, Tomasello C2, Marri M2, Salzano M2, Gasparini A2, Conicella E1. 1Emergency Department, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy. 2Anaesthesia and Intensive Care Department, Pain Center, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy. Abstract (Background)Complex regional pain syndrome (CRPS) is a disorder that is often challenging to treat and can be associated with a prolonged course of severe pain. Therapy of CRPS remains controversial; the pain often can be very difficult to control, and treatment includes medications, physical...

1.15 THE SOCIETY OF PHYSICAL THERAPY SCIENCE
2016 Jul;28(7):2175-7. doi: 10.1589/jpts.28.2175. Epub 2016 Jul 29 Effect of pain scrambler therapy on shoulder joint pain and range of motion in patients who had undergone arthroscopic rotator cuff repair for the first time. Lee DK1, Kim EK2. 1Department of Rehabilitation Science, Graduate School, Daegu University, Republic of Korea; Department of Physical Therapy, Sunhan Hospital, Republic of Korea. 2Department of Physical Therapy, Seonam University, Republic of Korea. Abstract [Purpose] This study aimed to determine the effect of pain scrambler therapy on shoulder joint pain and range of motion in patients who had undergone arthroscopic...

1.16 INTERNATIONAL JOURNAL OF STD & AIDS (STD) 2016 Jun 21. pii: 0956462416656688. [Epub ahead of print] Treatment of human immunodeficiency virus-related peripheral neuropathy with Scrambler Therapy: a case report. Smith TJ1, Auwaerter P2, Knowlton A3, Saylor D4, McArthur J4. 1From the Harry J. Duffey Family Palliative Care Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA tsmit136@jhmi.edu. 2Division of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, MD, USA. 3Department of Health Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 4Department of Neurology, Johns Hopkins School of Medicine, Baltimore,...